注意:干细胞治疗目前来说只可针对一种细胞类型的功能缺失,多种细胞的功能缺失可能还不太现实(Stem cell therapy will benefit patients with diseases that are caused by loss of function of just one type of cell, where the location of the loss of cells or injury are easily accessible and localized, except blood cells.)
Stem Cells in the Adult Human Retinal Pigment Epithelium and Their Therapeutic Potential(成人视网膜上皮干细胞的治疗潜力)
- Two Key words:
- Autologous(自体性):
- Allogeneic(异体性):每一个个体的HLA蛋白是不同的,除非你有一个双胞胎兄弟
- The examples about stem cell therapies:
- Stem cell for Retinal repair
- About age-related macular degeneration(AMD:老年性黄斑变性):一种神经退行性疾病
- About Retinal Pigment Epithelium:Replenish the Photoreceptors which are light responsive cells in the eye.(补充光受体细胞)补充:上图为病变的视网膜上皮细胞,其还带有Aβ蛋白治疗策略:在视网膜上皮细胞死亡之后且光受体细胞死亡之前就进行移植效果更好。
- The Plan:
- The proof of concept(概念证明):你的细胞是否会在动物模型中起作用?
- The model:视网膜上皮细胞不会更新光受体细胞
- Progress:
- The source of cells:挑战:前两种细胞如何保证他们就分化成我们的视网膜上皮细胞(在不同的时间段需要添加不同的细胞因子、生长因子)?
- The myths(悖论) about adult stem cells:
- About MSC(间充质干细胞):